cxcr4 antagonist 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40786	CXCR4 antagonist 1	CXCR4 antagonist 1
	CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.
TP1348	FC131 TFA (606968-52-9 free base)	FC131 TFA	HIV Protease , CXCR
	FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv activity.		HIV Protease , CXCR
T15805L	LY2510924 acetate(1088715-84-7 free base)		CXCR
	Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.		CXCR
T17208	USL311		CXCR
	USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing...		CXCR
T1739	WZ811		CXCR
	WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).		CXCR
TQ0174	Mavorixafor	AMD-070	CXCR
	Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC...		CXCR
T14665L	Motixafortide TFA(664334-36-5,Free)	TF 14016 TFA,BKT140 TFA,BL-8040 TFA,T140 TFA	CXCR
	Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression...		CXCR
TP1364L	ALX 40-4C acetate	ALX 40-4C acetate(143413-49-4 free base)	Apelin receptor , CXCR
	ALX 40-4C acetate is a CXCR4 inhibitor of the chemokine receptor (Ki = 1 μM) and suppresses the replication of X4 strains of HIV-1. ALX 40-4C acetate is an antagonist of the APJ receptor (IC50 = 2.9 μM).		Apelin receptor , CXCR
T1776	Plerixafor	JM3100,AMD 3100,AMD-3329	Virus Protease , HIV Protease , CXCR
	Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.		Virus Protease , HIV Protease , CXCR
T2375	BX471	BX 471,BX-471,ZK-811752	CCR
	BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.		CCR
T15805	LY2510924		Others
	LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).		Others
T14665	Motixafortide	BL-8040,BKT140 (4-fluorobenzoyl),TF14016	CXCR
	Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).		CXCR
T61650	CXCR4 antagonist 9
	CXCR4 antagonist 9 (Compound 2) is a potent CXCR4 antagonist displaying an IC50 of 15 nM. It effectively inhibits the cytosolic calcium increase induced by CXCL12, with an IC50 value of 1.3 nM [1].
T61409	CXCR4 antagonist 3
	CXCR4 antagonist 3 (compound 12a), an effective antagonist of CXCR4, exhibits an IC50 of 11 nM. It is a congener of TIQ15, showcasing exceptional properties such as CXCR4 antagonism, CYP 2D6 inhibition, metabolic stabili...
T27742	KRH-3955 Salt	KRH-3955,KRH3955,KRH 3955,KRH3955 Salt
	KRH-3955, a CXCR4 antagonist, is an orally bioavailable and extremely potent inhibitor of HIV-1 infection.
T61419	CXCR4 antagonist 5
	CXCR4 antagonist 5 (compound 23), a potent CXCR4 antagonist, exhibits high inhibition efficacy against CXCR4 with an IC50 value of 8.8 nM. It effectively suppresses CXCL12-induced cytosolic calcium increase (IC50 = 0.02 ...
T61420	CXCR4 antagonist 6
	CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM. It effectively inhibits the cytosolic calcium flux induced by CXCL12, achieving an IC50 of 0.25 nM. Moreover, CXCR4 anta...
T75803	FC131 TFA
	FC131 TFA is a CXCR4 antagonist, inhibits [ 125 I]-SDF-1 binding to CXCR4 , with an IC 50 of 4.5 nM. Anti- HIV activity [1] .
T64306	CXCR4 probe 1
	CXCR4 probe 1 (compound 5) is a potent and specific CXCR4-targeted PET tracer that acts on the CXCR4-specific antagonist TN14003 (IC50: 6.9 nM). The CXCR4 probe 1 has potential as a CXCR4-specific imaging probe for the d...
T75802	CTCE-9908 TFA
	CTCE-9908 TFA, a potent and selective CXCR4 antagonist, triggers mitotic catastrophe and cytotoxicity, and suppresses migration in ovarian cancer cells expressing CXCR4 [1] [2].